Pharmacokinetics of doxycycline polyphosphate after oral multiple dosing in humans

  title={Pharmacokinetics of doxycycline polyphosphate after oral multiple dosing in humans},
  author={Marie Claude Saux and J. Mosser and Henri Pontagnier and Bingshuang Leng},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  • M. Saux, J. Mosser, B. Leng
  • Published 2010
  • Medicine
  • European Journal of Drug Metabolism and Pharmacokinetics
SummaryNine healthy volunteers received oral multiple doses of doxycycline polyphosphate for 6 days. Three different dosage schedules were given and the time concentration data obtained was used to determine the best protocol for producing effective serum antibiotic levels during a complete period of treatment with the aid of a mathematical simulation programme. This protocol consisted of the administration of a 200 mg loading dose on the first day, followed by a 100 mg maintenance dose every… 
Pharmacokinetic study of doxycycline polyphosphate after simultaneous ingestion of milk
SummaryPharmacokinetic parameters of doxycycline polyphosphate were studied in healthy volunteers after oral administration of a single 200 mg dose of this antibiotic with a breakfast containing or
Synthesis and antibacterial activity of doxycycline neoglycosides.
The use of aminosugars in the context of neoglycosylation is extended via a simple two-step strategy anticipated to be broadly applicable for neoglycorandomization.
The pharmacology of antibiotic therapy in hidradenitis suppurativa
Antibiotic therapy is an effective treatment of patients with HS but probably, in the next five years, many therapeutic options will be available, which will change the way the authors manage the disease, especially the moderate-to-severe forms of HS.
Dosierungsbesonderheiten am Anfang und Ende einer Therapie
Solche Arzneimittel sollten nach mehrwochiger Therapie nur vorsichtig wieder abgesetzt werden, um zum Teil lebensbedrohliche Entzugssyndrome wie hypertensive Krisen nach Clonidin-Entzug oder Entzugsanfalle nach Absetzen v...


Pharmacokinetic study of doxycycline polyphosphate (PPD), Hydrochloride (CHD) and base (DB)
F Fluorimetric analysis of some of the samples confirmed the values obtained, with the exception of a few parameters such as Vd and clearance, which were lower.
Interactions with the Absorption of Tetracyclines
The pharmacokinetic interactions in absorption of tetracyclines are likely to be clinically significant in cases where the infecting pathogens are moderately resistant to tetrACYclines and relatively high serum concentrations are needed for proper bacteriostasis.
Comparative Susceptibility of Anaerobic Bacteria to Minocycline, Doxycycline, and Tetracycline
The comparative susceptibility of 622 recent clinical isolates of anaerobic bacteria to minocycline, doxycycline, and tetracycline was determined by an agar-dilution technique and the enhanced activity of minocyCline was particularly striking for Peptococcus asaccharolyticus, P. magnus, and Bacteroides melaninogenicus.
IGPHARM: interactive graphic package for pharmacokinetic analysis.
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