Pharmacokinetics of doxycycline polyphosphate after oral multiple dosing in humans

@article{Saux2010PharmacokineticsOD,
  title={Pharmacokinetics of doxycycline polyphosphate after oral multiple dosing in humans},
  author={Marie Claude Saux and J. Mosser and Henri Pontagnier and Bingshuang Leng},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2010},
  volume={7},
  pages={123-130}
}
  • M. Saux, J. Mosser, B. Leng
  • Published 2010
  • Medicine
  • European Journal of Drug Metabolism and Pharmacokinetics
SummaryNine healthy volunteers received oral multiple doses of doxycycline polyphosphate for 6 days. Three different dosage schedules were given and the time concentration data obtained was used to determine the best protocol for producing effective serum antibiotic levels during a complete period of treatment with the aid of a mathematical simulation programme. This protocol consisted of the administration of a 200 mg loading dose on the first day, followed by a 100 mg maintenance dose every… 
Pharmacokinetic study of doxycycline polyphosphate after simultaneous ingestion of milk
SummaryPharmacokinetic parameters of doxycycline polyphosphate were studied in healthy volunteers after oral administration of a single 200 mg dose of this antibiotic with a breakfast containing or
Synthesis and antibacterial activity of doxycycline neoglycosides.
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Solche Arzneimittel sollten nach mehrwochiger Therapie nur vorsichtig wieder abgesetzt werden, um zum Teil lebensbedrohliche Entzugssyndrome wie hypertensive Krisen nach Clonidin-Entzug oder Entzugsanfalle nach Absetzen v...

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