Pharmacokinetics of divided-dose ifosfamide.

  title={Pharmacokinetics of divided-dose ifosfamide.},
  author={Robert L. Nelson and Larry Allen and Patrick J. Creaven},
  journal={Clinical pharmacology and therapeutics},
  volume={19 3},
The pharmacokinetics of a divided-dose schedule of ifosfamide was investigated in 3 patients given 1, 600 to 2,400 mg/sq m/day for 3 days, with a second course of treatment 21 days later. In contrast to the biexponential decay seen with single-dose ifosfamide (5,000 mg/sq m), data for divided low-dose plasma ifosfamide are best fitted by a monoexponential decay function compatible with a one-compartment open model. Plasma half-life for ifosfamide given in the divided-dose schedule was 6.9 hr… CONTINUE READING
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