Pharmacokinetics of diltiazem after intravenous and oral administration

  title={Pharmacokinetics of diltiazem after intravenous and oral administration},
  author={Ph. Hermann and S. D. Rodger and G. Remones and Jean Paul Th{\'e}not and Dennis London and Paolo Lucio Morselli},
  journal={European Journal of Clinical Pharmacology},
The kinetic profile of diltiazem, a novel calcium antagonist, was studied in 12 volunteers following oral (60 mg) and intravenous (15 mg) administration. After i.v. administration biphasic elimination was observed, with a distribution half-life of 0.3±0.2 h and an elimination half-life of 3.1±1.0 h; the apparent volume of distribution was 5.3±1.71/kg and the total clearance was 1.28±0.48 l/kg/h. After the oral dose the elimination phase had a half-life of 3.2±1.3 h. The absolute bioavailability… CONTINUE READING
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