Pharmacokinetics of diazepam in disordered liver function

Abstract

The plasma elimination curves of diazepam following intravenous administration of 10 mg were studied in nine patients with cirrhosis of the liver and four patients without liver disease. The data were analyzed according to a two compartment model. The mean biological half-life (T/2) of diazepam was increased five-fold in patients with cirrhosis compared to… (More)
DOI: 10.1007/BF00609469

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