• Corpus ID: 94165368

Pharmacokinetics of diammine(l,l cyclobutanedi carboxylato) platinum(II) (carboplatin) after intravenous administration

@article{Elferink1987PharmacokineticsOD,
  title={Pharmacokinetics of diammine(l,l cyclobutanedi carboxylato) platinum(II) (carboplatin) after intravenous administration},
  author={F. Elferink and Wim J. F. Vijgh and Ina Klein and Jan Baptist Vermorken and Helen E. Gall and Herbert Michael Pinedo},
  journal={Cancer treatment reports},
  year={1987},
  volume={71},
  pages={1231-1237}
}
Pharmacokinetics of the cisplatin analog carboplatin were studied in ovarian cancer patients who received short-term iv infusions of 290-370 mg/m2. Platinum (Pt) was determined by atomic absorption spectrometry in plasma ultrafiltrate up to 24 hours and in plasma and urine up to 5 days following infusion. Carboplatin was determined in plasma ultrafiltrate and in urine by high-performance liquid chromatography with electrochemical detection. The final half-life of total Pt in plasma was 5.8… 
Pharmacokinetics of carboplatin after intraperitoneal administration
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Overall pharmacokinetic parameters of carboplatin and platinum in plasma were comparable after i.
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Findings suggest that zeniplatin has a pharmacokinetic profile similar to that of carboplatin, and could be recovered in the urine within 24 h.
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Values of volume of distribution at steady-state (Vdss) were higher following continuous infusion administration as well as percentage decrease in platelets (at the nadir 4 weeks after the start of infusion) and AUC X normalised radiation field area, consistent with results from other studies.
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There appears to be a more clearly defined AUC-response relationship for ovarian cancer than for other malignancies, with an AUC of between 5 and 7 mg/ml · min being associated with the maximal response rate].
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Patients receiving the combination of carboplatin given in combination with three doses of amifostine had a longer final half-life of ultrafilterable platinum species and the impact of these changes on the area under the concentration-time curves of the ultra filters was hardly noticeable but led to a significant increase in patients with an impaired renal function.
Pharmacokinetics of high-dose carboplatin in children undergoing high-dose chemotherapy and autologous stem cell transplantation with BSA-based dosing
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Positive correlations between the renal functions and the AUCs were mild to moderate, but they were stronger in nephrectomized patients, and optimal high-dose carboplatin dosing method and optimal target A UCs for the different tumors need further analysis.
Pharmacokinetics of oxaliplatin in patients with normal versus impaired renal function
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Carboplatin dosage: prospective evaluation of a simple formula based on renal function.
  • A. Calvert, D. Newell, E. Wiltshaw
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1989
TLDR
The formula provides a simple and consistent method of determining carboplatin dose in adults and will not be influenced by previous or concurrent myelosuppressive therapy or supportive measures, and is applicable to combination and high-dose studies as well as conventional single-agent therapy, although the target AUC will need to be redefined for combination chemotherapy.
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