Pharmacokinetics of dextropropoxyphene in acute poisoning.

  title={Pharmacokinetics of dextropropoxyphene in acute poisoning.},
  author={Jens Schou and Helle Riis Angelo and Walter L. Wan Dam and Kjeld Buus Jensen and J M Christensen},
  journal={Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement},
Dextropropoxyphene (DP) is a commonly used medicament for suicide attempts in Denmark. Death may occur from respiratory depression or cardiac arrest. Mechanical hyperventilation which induces hypocapnia seems to reduce the occurrence of cardiac complications. In an attempt to relate the clinical events to the plasma concentrations of DP and the major metabolite norpropoxyphene (NP) we studied patients with acute poisoning treated either for 48 h with induced hypocapnia by hyperventilation or… CONTINUE READING