Pharmacokinetics of dexamethasone and its phosphate ester.

  title={Pharmacokinetics of dexamethasone and its phosphate ester.},
  author={Peter Joerg Rohdewald and Helmut W M{\"o}llmann and Juergen Barth and J. Rehder and Hartmut Derendorf},
  journal={Biopharmaceutics & drug disposition},
  volume={8 3},
Dexamethasone in form of its phosphate was given intravenously in two different doses (1.5 mg kg-1 and 15 mg). Plasma levels of the ester and dexamethasone were measured and pharmacokinetic parameters were calculated. The results indicate no dose-dependency of the pharmacokinetic parameters in the investigated range for dexamethasone. Conversion from the prodrug to the active form was rapid; maximum dexamethasone plasma concentrations were reached after 10 min. The results were verified by… CONTINUE READING

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