Pharmacokinetics of dexamethasone and its effect on adrenal gland function in the dog.

The pharmacokinetics of dexamethasone (DXM) was studied in a group of 5 dogs given DXM alcohol or DXM 21-isonicotinate (as a solution) IV or IM (1 mg/kg of body weight) and DXM 21-isonicotinate (as a suspension) IM (0.1 or 1 mg/kg). Plasma concentrations were determined, using a high-performance liquid chromatography method. After IV administration, the… (More)