Pharmacokinetics of dexamethasone after intravenous and intramuscular administration in pigs.

  title={Pharmacokinetics of dexamethasone after intravenous and intramuscular administration in pigs.},
  author={Heidi Wyns and Evelyne Meyer and Anneleen Watteyn and Elke Plessers and Siegrid De Baere and Patrick de Backer and Siska Croubels},
  journal={Veterinary journal},
  volume={198 1},
The pharmacokinetics of dexamethasone (DEX) were investigated after an intravenous (IV) or intramuscular (IM) bolus injection of 0.3mg/kg bodyweight DEX sodium phosphate in pigs. The plasma concentrations of DEX were determined using a validated high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method and the pharmacokinetics were determined by one-compartmental analysis. The mean area under the plasma concentration-time curve and the mean elimination half-life were 133… CONTINUE READING
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