Pharmacokinetics of dapsone gel, 5% for the treatment of acne vulgaris.

@article{Thiboutot2007PharmacokineticsOD,
  title={Pharmacokinetics of dapsone gel, 5% for the treatment of acne vulgaris.},
  author={Diane M. Thiboutot and Jonathan Willmer and Harry Sharata and Rebat M. Halder and S. J. Garrett},
  journal={Clinical pharmacokinetics},
  year={2007},
  volume={46 8},
  pages={697-712}
}
BACKGROUND Oral dapsone has been available for over 60 years and has been used to treat severe acne vulgaris; however, the oral formulation is known to cause dose-dependent haematological reactions and is currently indicated only for diseases such as dermatitis herpetiformis and Hansen's disease. A gel formulation of dapsone was recently developed to treat acne vulgaris. As dapsone is administered topically, it was expected that systemic absorption would be considerably lower than that observed… CONTINUE READING

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