Pharmacokinetics of cyclosporine and steady-state aspirin during coadministration.

  title={Pharmacokinetics of cyclosporine and steady-state aspirin during coadministration.},
  author={John M. Kovarik and Edgar A. Mueller and Mariya Gaber and Atholl Johnston and Eberhard J{\"a}hnchen},
  journal={Journal of clinical pharmacology},
  volume={33 6},
Anecdotal reports from clinical trials assessing the use of cyclosporine in the treatment of rheumatoid arthritis suggest an association between enhanced renal impairment and combined use of cyclosporine with nonsteroidal anti-inflammatory drugs. To explore possible pharmacokinetic contributions to this phenomenon, a randomized, two-period crossover investigation was performed in 24 healthy volunteers in which a single oral dose of 300 mg cyclosporine was administered alone and on day 10 of… CONTINUE READING

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