Pharmacokinetics of combined doxorubicin and paclitaxel in mice.

  title={Pharmacokinetics of combined doxorubicin and paclitaxel in mice.},
  author={Daniel L. Gustafson and Andrea L. Merz and Michael E. Long},
  journal={Cancer letters},
  volume={220 2},
Doxorubicin (DOX) has excellent antitumor activity when combined with paclitaxel (PTX) and this combination is used as first-line treatment for metastatic breast cancer. Results from clinical studies on pharmacokinetic interaction of these agents are not conclusive and pre-clinical studies are still needed. Pharmacokinetic studies were carried out in female Balb/c mice with combined DOX (6 mg/kg) and PTX (10 mg/kg) treatment. Combined treatment with PTX and DOX leads to alterations in the… CONTINUE READING

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