Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication

@article{Kirchheiner2007PharmacokineticsOC,
  title={Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication},
  author={Julia Kirchheiner and Helmut Schmidt and Mladen Vassilev Tzvetkov and J. Karlijn van Keulen and J{\"o}rn L{\"o}tsch and Ivar Roots and J{\"u}rgen Brockm{\"o}ller},
  journal={The Pharmacogenomics Journal},
  year={2007},
  volume={7},
  pages={257-265}
}
Codeine is an analgesic drug acting on μ-opiate receptors predominantly via its metabolite morphine, which is formed almost exclusively by the genetically polymorphic enzyme cytochrome P450 2D6 (CYP2D6). Whereas it is known that individuals lacking CYP2D6 activity (poor metabolizers, PM) suffer from poor analgesia from codeine, ultra-fast metabolizers (UM) due to the CYP2D6 gene duplication may experience exaggerated and even potentially dangerous opioidergic effects and no systematical study… CONTINUE READING

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