Pharmacokinetics of clomipramine, an antidepressant, in poloxamer 407-induced hyperlipidaemic model rats.

@article{Kobuchi2011PharmacokineticsOC,
  title={Pharmacokinetics of clomipramine, an antidepressant, in poloxamer 407-induced hyperlipidaemic model rats.},
  author={Shinji Kobuchi and Keizo Fukushima and Masakazu Shibata and Yukako Ito and Nobuyuki Sugioka and Kanji Takada},
  journal={The Journal of pharmacy and pharmacology},
  year={2011},
  volume={63 4},
  pages={515-23}
}
OBJECTIVE This study was undertaken to investigate the effects of hyperlipidaemia on the pharmacokinetics of clomipramine, an antidepressant, particularly addressing the change of clomipramine distribution to plasma components in poloxamer 407-induced hyperlipidaemia model rats. METHODS Clomipramine pharmacokinetic studies in hyperlipidaemic rats were performed with clomipramine continuous infusion. Furthermore, clomipramine protein binding and distribution to the brain and plasma components… CONTINUE READING