Pharmacokinetics of clarithromycin in bronchial epithelial lining fluid.

@article{Kikuchi2008PharmacokineticsOC,
  title={Pharmacokinetics of clarithromycin in bronchial epithelial lining fluid.},
  author={Eiki Kikuchi and Koichi Yamazaki and Junko Kikuchi and Naoki Hasegawa and Satoru Hashimoto and Akitoshi Ishizaka and Masaharu Nishimura},
  journal={Respirology},
  year={2008},
  volume={13 2},
  pages={221-6}
}
BACKGROUND AND OBJECTIVE BAL is an established technique for measuring antibiotic concentrations in the epithelial lining fluid (ELF) of the bronchiolar-alveolar regions. However, the results may not reflect concentrations in bronchial regions. Bronchoscopic microsampling (BMS) is a technique for repeated sampling of bronchial ELF. The objective of the present study was to determine the time versus concentration profile of clarithromycin and its active metabolite, 14-hydroxy-clarithromycin, in… CONTINUE READING
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