Pharmacokinetics of cisplatin in analbuminemic rats.

@article{Takada1999PharmacokineticsOC,
  title={Pharmacokinetics of cisplatin in analbuminemic rats.},
  author={Kanji Takada and Takeshi Kawamura and Maya Inai and Satohiro Masuda and Takahiro Oka and Yukako Yoshikawa and Nobuhito Shibata and Hiroshi Yoshikawa and Osamu Ike and Hajime Wada and Shinichiro Hitomi},
  journal={Biopharmaceutics & drug disposition},
  year={1999},
  volume={20 9},
  pages={421-8}
}
The effect of protein binding on the pharmacokinetics of cisplatin (cis-diamminedichloroplatinum (II); CDDP) has been studied in analbuminemic rats, which genetically lack albumins, in comparison with normal rats. CDDP was reported to highly bind to serum components, and the major binder was thought to be an albumin. However, there were no significant… CONTINUE READING