Pharmacokinetics of ciprofloxacin XR (1000 mg) versus levofloxacin (500 mg) in plasma and urine of male and female healthy volunteers receiving a single oral dose.

@article{Wagenlehner2006PharmacokineticsOC,
  title={Pharmacokinetics of ciprofloxacin XR (1000 mg) versus levofloxacin (500 mg) in plasma and urine of male and female healthy volunteers receiving a single oral dose.},
  author={Florian M. E. Wagenlehner and Martina Kinzig-Schippers and Uwe Tischmeyer and Christine M Wagenlehner and Fritz Soergel and Axel A H Dalhoff and Kurt G. Naber},
  journal={International journal of antimicrobial agents},
  year={2006},
  volume={27 1},
  pages={7-14}
}
The new extended-release formulation of ciprofloxacin (ciprofloxacin XR) was designed for once-daily administration in the treatment of urinary tract infection (UTI). The aim of this study was to compare concentrations in plasma, urinary excretion (UE) and pharmacokinetic parameters of ciprofloxacin XR (1000 mg) versus those of levofloxacin (500 mg) in healthy volunteers receiving a single oral dose. In this randomised crossover study, 12 volunteers (6 males, 6 females) received a single oral… CONTINUE READING

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