Pharmacokinetics of chlorpromazine and key metabolites

@article{Yeung2004PharmacokineticsOC,
  title={Pharmacokinetics of chlorpromazine and key metabolites},
  author={P. K. F. Yeung and John W. Hubbard and Elarien D. Korchinski and K. K. Midha},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={45},
  pages={563-569}
}
SummaryA study was carried out in 11 healthy young men to investigate the pharmacokinetics of chlorpromazine (CPZ) after a bolus intravenous (IV) dose (10 mg) and three single oral doses (25, 50 and 100 mg), with a washout period of two weeks between doses. Plasma levels of CPZ, CPZ N-oxide (CPZNO), CPZ sulfoxide (CPZSO) and both free and conjugated 7-hydroxy-CPZ (7-HOCPZ) were measured by extraction radioimmunoassays.CPZ exhibited multicompartmental pharmacokinetics in most subjects. There was… 
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Transcriptomic data derived from shortand long-term cultured primary human hepatocytes exposed to the well known human hepatotoxin chlorpromazine (CPZ) suggested features of inflammation could be related to the idiosyncratic hepatotoxic effects of CPZ in humans.
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