Pharmacokinetics of chlorpromazine after single and chronic dosage

@article{Dahl1977PharmacokineticsOC,
  title={Pharmacokinetics of chlorpromazine after single and chronic dosage},
  author={Svein G. Dahl and Roald E. Strandjord},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1977},
  volume={21}
}
  • S. Dahl, R. Strandjord
  • Published 1 April 1977
  • Medicine, Psychology
  • Clinical Pharmacology & Therapeutics
Plasma concentrations of chlorpromazine and its sulfoxide were measured after single intramuscular, single oral, and multiple oral doses of chlorpromazine. In four out of nine patients, intramuscular doses gave stable chlorpromazine plasma levels which were maintained for 12 hr or longer. Chlorpromazine sulfoxide was found in plasma from all patients after oral doses but not after intramuscular doses, which indicates that sulfoxidation took place presystemically. The biologic availability of… 
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