Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele.

@article{Kidd1999PharmacokineticsOC,
  title={Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele.},
  author={Robert Kidd and Arthur B. Straughn and Maur{\'i}cio C. Meyer and Joyce Blaisdell and Joyce A. Goldstein and James T Dalton},
  journal={Pharmacogenetics},
  year={1999},
  volume={9 1},
  pages={71-80}
}
Genetic polymorphisms in the cytochrome P450 (CYP) family are widely known to contribute to interindividual differences in the pharmacokinetics of many drugs. Several alleles for the CYP2C9 gene have been reported. Individuals homozygous for the Leu359 variant (CYP2C9*3) have been shown to have significantly lower drug clearances compared with Ile359 (CYP2C9*1) homozygous individuals. A male Caucasian who participated in six bioavailability studies in our laboratory over a period of several… CONTINUE READING

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