Pharmacokinetics of chlordesmethyldiazepam after single-dose oral administration in humans

@article{Bareggi2010PharmacokineticsOC,
  title={Pharmacokinetics of chlordesmethyldiazepam after single-dose oral administration in humans},
  author={Silvio R. Bareggi and Rodolfo Pirola and S Eva and Luigi Zecca},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2010},
  volume={11},
  pages={171-174}
}
  • S. BareggiR. Pirola L. Zecca
  • Published 1 July 1986
  • Medicine, Biology
  • European Journal of Drug Metabolism and Pharmacokinetics
SummaryThe pharmacokinetics of chlordemethyldiazepam — a pharmacologically very active new 1,4-benzodiazepine derivative — in healthy subjects after administration of a single oral dose of 2 mg, was studied. Peak concentrations were reached in 1.2 ± 0.2 hours. Plasma levels declined with a biphasic pattern, and the elimination phase had a half-life of 82.9 ± 14.1 hours. The concentrations of the main metabolite of chlordemethyldiazepam, lorazepam, were about 7% of those of the parent compound… 

Quantification of chlordesmethyldiazepam by liquid chromatography-tandem mass spectrometry: application to a cloxazolam bioequivalence study.

A rapid, sensitive and specific LC-MS/MS method was developed and validated for quantifying chlordesmethyldiazepam (CDDZ or delorazepam), the active metabolite of cloxazolam, in human plasma and indicated bioequivalence since all ratios were as proposed by FDA and ANVISA.

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