Pharmacokinetics of ceftriaxone in liver-transplant recipients.


The disposition of ceftriaxone was studied after a single 2 g intravenous dose in seven patients 3 to 5 days after liver transplantation. Ceftriaxone concentrations in plasma, urine, and bile were measured by HPLC, and plasma protein binding was determined by equilibrium dialysis. Plasma protein binding was nonlinear, and the unbound fraction varied between… (More)


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@article{Toth1991PharmacokineticsOC, title={Pharmacokinetics of ceftriaxone in liver-transplant recipients.}, author={Art Toth and Heba Y Abdallah and Raman Venkataramanan and Lewis W. Teperman and G Halsf and Marlene Rabinovitch and Gilbert J. Burckart and T. E. Starzl}, journal={Journal of clinical pharmacology}, year={1991}, volume={31 8}, pages={722-8} }