Pharmacokinetics of ceftriaxone administered by the intravenous, intramuscular or subcutaneous routes to dogs.

@article{Rebuelto2002PharmacokineticsOC,
  title={Pharmacokinetics of ceftriaxone administered by the intravenous, intramuscular or subcutaneous routes to dogs.},
  author={Marcela Rebuelto and Gabriela A Albarellos and Luis A Ambros and Ver{\'o}nica Kreil and Laura Montoya and R R Bonafine and Peter Otero and Ruben Hallu},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2002},
  volume={25 1},
  pages={73-6}
}
The purpose of this study was to investigate the pharmacokinetics of ceftriaxone after single intravenous (i.v.), intramuscular (i.m.) and subcutaneous (s.c.) doses in healthy dogs. Six mongrel dogs received ceftriaxone (50 mg/kg) by each route in a three-way crossover design. Blood samples were collected in predetermined times after drug administration. Results are reported as mean +/- standard deviation (SD). Total body clearance (Cl(t)) and apparent volume of distribution (V(z)) for the i.v… CONTINUE READING