Pharmacokinetics of ceftiofur sodium and ceftiofur crystalline free acid in neonatal foals.

@article{Hall2011PharmacokineticsOC,
  title={Pharmacokinetics of ceftiofur sodium and ceftiofur crystalline free acid in neonatal foals.},
  author={Tara L. Hall and Lisa A Tell and Scott E Wetzlich and Jacob McCormick and L W Fowler and N Pusterla},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2011},
  volume={34 4},
  pages={403-9}
}
Ceftiofur, a third generation cephalosporin, demonstrates in vitro efficacy against microorganisms isolated from septicemic neonatal foals. This pharmacokinetic study evaluated the intravenous and subcutaneous administration of ceftiofur sodium (5 mg/kg body weight; n = 6 per group) and subcutaneous administration of ceftiofur crystalline free acid (6.6 mg/kg body weight; n = 6) in healthy foals. Plasma ceftiofur- and desfuroylceftiofur-related metabolite concentrations were measured using high… CONTINUE READING

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