Pharmacokinetics of cefotaxime.

  title={Pharmacokinetics of cefotaxime.},
  author={K P Fu and P Aswapokee and Irwin Ho and C Matthijssen and Harold C. Neu},
  journal={Antimicrobial agents and chemotherapy},
  volume={16 5},
The pharmacokinetics of cefotaxime after intramuscular injection and intravenous infusion were determined. The mean peak serum level after the 500-mg intramuscular dose was 11.7 micrograms/ml, and it was 20.5 micrograms/ml after a 1,000-mg dose. The serum half-life was 1.2 and 1.3 h, respectively for the two doses. The apparent fractional volumes of distribution of 32 and 37 liters were not significantly different for the two doses, and the fractional serum clearance was approximately 315 ml… CONTINUE READING