Pharmacokinetics of cefoperazone in newborn infants.

  title={Pharmacokinetics of cefoperazone in newborn infants.},
  author={Joseph B Philips and Karin Braune and W R Ravis and George Cassady and Harvey Dillon},
  journal={Pediatric pharmacology},
  volume={4 3},
We studied the disposition of two 100 mg/kg doses of cefoperazone given intravenously 12 hr apart in ten newborn infants. Peak levels were a mean 352 +/- SD 75 and 371 +/- 68 micrograms/ml immediately after the first and second dose, respectively, with corresponding troughs of 60 +/- 10 and 76 +/- 28 mcg/ml 12 hr later. Mean half-life was 6.5 +/- 0.9 hr and decreased with increasing gestational age and birthweight. Steady-state volume of distribution averaged 410 +/- 40 ml/kg and total… CONTINUE READING

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