Pharmacokinetics of carbamazepine Part I: a new bioequivalency parameter based on a relative bioavailability trial

@article{Kayali1994PharmacokineticsOC,
  title={Pharmacokinetics of carbamazepine Part I: a new bioequivalency parameter based on a relative bioavailability trial},
  author={Aycil Kayali and I. Tuğlular and Mustafa Ertas},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={1994},
  volume={19},
  pages={319-325}
}
The relative bioavailability of three carbamazepine generics available in Turkey, were investigated in 5 healthy male volunteers. When issuing a license to any drug, FDA stipulates at most a difference of 20% from the reference drug only in peak concentration and AUC (area under the curve). This condition may cause some problems, as two generics of the same… CONTINUE READING