Pharmacokinetics of bupivacaine during postoperative epidural infusion: enantioselectivity and role of protein binding.

@article{Veering2002PharmacokineticsOB,
  title={Pharmacokinetics of bupivacaine during postoperative epidural infusion: enantioselectivity and role of protein binding.},
  author={Bernadette Th Veering and Anton G. L. Burm and Hilde-Marieken Feyen and Wim Olieman and John H M Souverijn and Jack W van Kleef},
  journal={Anesthesiology},
  year={2002},
  volume={96 5},
  pages={1062-9}
}
BACKGROUND Changing plasma protein concentrations may affect the protein binding and pharmacokinetics of drugs in the postoperative period. This study examined the effect of postoperative increases (in response to surgery) in plasma alpha1-acid-glycoprotein (AAG) concentrations on the plasma concentrations of the enantiomers of bupivacaine during continuous… CONTINUE READING