Pharmacokinetics of buccal and intranasal lorazepam in healthy adult volunteers

@article{Anderson2011PharmacokineticsOB,
  title={Pharmacokinetics of buccal and intranasal lorazepam in healthy adult volunteers},
  author={Mark A Anderson and Parag Tambe and Helen Sammons and Hussain Mulla and Richard Cole and Imti Choonara},
  journal={European Journal of Clinical Pharmacology},
  year={2011},
  volume={68},
  pages={155-159}
}
To investigate the plasma-concentration profile of lorazepam when administered by the intranasal and buccal routes to determine their utility for the treatment of prolonged seizures. On two occasions separated by at least 7 days washout, 12 healthy adult male volunteers received 2 mg of lorazepam via the intranasal or buccal route. Blood samples were… CONTINUE READING