Pharmacokinetics of bevacizumab after topical, subconjunctival, and intravitreal administration in rabbits.

@article{Nomoto2009PharmacokineticsOB,
  title={Pharmacokinetics of bevacizumab after topical, subconjunctival, and intravitreal administration in rabbits.},
  author={Hiroyuki Nomoto and Fumio Shiraga and Noriyuki Kuno and Erika Kimura and Shinobu Fujii and Katsuhiko Shinomiya and Alex K. Nugent and Kazuyuki Hirooka and Tetsuya Baba},
  journal={Investigative ophthalmology & visual science},
  year={2009},
  volume={50 10},
  pages={4807-13}
}
PURPOSE To investigate the pharmacokinetics of bevacizumab in rabbits for three different routes of administrations: intravitreal injection, subconjunctival injection, and eye drops. METHODS Pigmented rabbits received bevacizumab in one eye by topical eye drops (1.25 mg/0.05 mL six times daily for the first 7 days), single subconjunctival injection (1.25… CONTINUE READING