Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects

  title={Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects},
  author={Gayle A. Baldock and R. R. Brodie and Leslie F Chasseaud and T. Taylor and L. M. Walmsley and Bernardo Catanese},
  journal={Biopharmaceutics \& Drug Disposition},
The pharmacokinetics of the anti‐inflammatory drug benzydamine were determined after intravenous infusion of 5 mg to six healthy male subjects. Benzydamine was characterized as a drug of relatively low systemic clearance (ca. 160 ml min−1) but high volume of distribution (ca. 1101); the apparent terminal half‐life in plasma was ca. 8h. Benzydamine was well absorbed after oral administration, as indicated by a mean systemic availability of 87 per cent. However, absorption of the drug was low… 
Pharmacokinetics of benzydamine in dairy cows following intravenous or intramuscular administration
Five lactating cows were given benzydamine hydrochloride by rapid intravenous and intramuscular injection in a crossover design and the bioavailability, pharmacokinetic parameters and excretion in milk of Benzydamine were evaluated.
Pharmacology of benzydamine
Benzydamine is a topical anti-inflammatory drug which is widely available and used topically for the treatment of the mouth. It is also used as a gel for application to inflamed joints. It has
Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice
Plasma concentrations of benzydamine and its primary N-oxide and N-demethylated metabolites were investigated in control TK-NOG mice, in humanized-liver mice, and in mice whose liver cells had been ablated with ganciclovir.
Benzydamine is a topical anti-inflammatory drug which is widely available and used topically for the treatment of the mouth and as a gel for application to inflamed joints and has physicochemical properties and pharmacological activities which differ markedly from those of the aspirin-line non- steroidal anti- inflammatory drugs.
Ingestions of benzydamine-containing vaginal preparations
This is the largest report of benzydamine ingestions and the outstanding feature was the high percentage of neurological manifestations in children and adults, mainly hallucinations, following the ingestion of an over-the-counter product.
A case of benzydamine HCL intoxication
It is suggested that if a patient is presented with somnolence and visual hallucinations, drug intoxication should be considered in the differential diagnosis of acute benzydamine HCL intoxication.
Phase I Study in Healthy Women of a Novel Antimycotic Vaginal Ovule Combining Econazole and Benzydamine
The tested fixed-dose combination showed a good safety profile consistently with the known tolerability of both active substances, and the confirmed low bioavailability of the drugs excludes the possibility of any accumulation effects and limits the risk of undesired systemic effects.
Local irritant effects of topical oral sprays on oral mucosa in mice
The histopathologic changes noted in the oral mucosa of mice after topical application of 3 widely prescribed antibacterial products are investigated and the local irritant effects of topical oral sprays should be considered when treatment is selected for patients with oropharyngeal disorder.
Effect of lipophilic counter-ions on membrane diffusion of benzydamine.
  • V. Sarveiya, J. Templeton, H. Benson
  • Chemistry
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2005
Hallucinations after Ingesting a High Dose of Benzydamine Hydrochloride
  • Burak Can, Ihsan Oz, H. Ozer, T. Şimşek
  • Medicine
    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2016
An 18-year-old male patient who attempted suicide had swallowed 20 pieces of candy containing 50 mg BH and was brought to the emergency room by his family, where hallucinations were ongoing and hospitalization was suggested.


Concentration of benzydamine in vaginal mucosa following local application: an experimental and clinical study.
Benzydamine assayed in seven volunteers with healthy vaginas showed that the drug cannot be detected in the plasma, which justified the local benefits from benzydamine treatment of vaginal inflammation.
Serum levels of benzydamine following the topical use of this drug in gynecology.
Data are a further confirmation that, whenever possible, topical use is preferable to systemic use in order to reduce the incidence of systemic side effects to a minimum and to obtain a more selective therapy.
Pharmacokinetics of benzydamine.
The pharmacokinetics of benzydamine are reported after both topical and systemic administration, and the available data are reviewed with particular reference to its topical use.
The application of statistical moment theory to the evaluation ofin vivo dissolution time and absorption time
The appropriate use of a logarithmic trapezoidal equation for calculating the area under the moments curve (AUMC) is shown to increase the accuracy of estimating MDT.
Benzydamine: a critical review of clinical data.
It was concluded that benzydamine applied locally consistently produced relief of pain with a demonstratable antiinflammatory effect and caused infrequent side-effects and was considered a safe and effective method of producing pain relief by local application.