Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects

@article{Baldock1991PharmacokineticsOB,
  title={Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects},
  author={Gayle A. Baldock and R. R. Brodie and Leslie F Chasseaud and T. Taylor and L. M. Walmsley and Bernardo Catanese},
  journal={Biopharmaceutics \& Drug Disposition},
  year={1991},
  volume={12}
}
The pharmacokinetics of the anti‐inflammatory drug benzydamine were determined after intravenous infusion of 5 mg to six healthy male subjects. Benzydamine was characterized as a drug of relatively low systemic clearance (ca. 160 ml min−1) but high volume of distribution (ca. 1101); the apparent terminal half‐life in plasma was ca. 8h. Benzydamine was well absorbed after oral administration, as indicated by a mean systemic availability of 87 per cent. However, absorption of the drug was low… 
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References

SHOWING 1-7 OF 7 REFERENCES
Concentration of benzydamine in vaginal mucosa following local application: an experimental and clinical study.
TLDR
Benzydamine assayed in seven volunteers with healthy vaginas showed that the drug cannot be detected in the plasma, which justified the local benefits from benzydamine treatment of vaginal inflammation.
Serum levels of benzydamine following the topical use of this drug in gynecology.
TLDR
Data are a further confirmation that, whenever possible, topical use is preferable to systemic use in order to reduce the incidence of systemic side effects to a minimum and to obtain a more selective therapy.
Pharmacokinetics of benzydamine.
TLDR
The pharmacokinetics of benzydamine are reported after both topical and systemic administration, and the available data are reviewed with particular reference to its topical use.
The application of statistical moment theory to the evaluation ofin vivo dissolution time and absorption time
TLDR
The appropriate use of a logarithmic trapezoidal equation for calculating the area under the moments curve (AUMC) is shown to increase the accuracy of estimating MDT.
Benzydamine: a critical review of clinical data.
TLDR
It was concluded that benzydamine applied locally consistently produced relief of pain with a demonstratable antiinflammatory effect and caused infrequent side-effects and was considered a safe and effective method of producing pain relief by local application.