Pharmacokinetics of bambuterol in healthy subjects.

  title={Pharmacokinetics of bambuterol in healthy subjects.},
  author={Lars Nyberg and Johan Rosenborg and Eva Weibull and Siv J{\"o}nsson and Betty M Kennedy and Marita Nilsson},
  journal={British journal of clinical pharmacology},
  volume={45 5},
AIMS To study the pharmacokinetics and bioavailability of the prodrug bambuterol and its bronchodilator moiety terbutaline in healthy subjects. METHODS Eight healthy subjects (four women) received intravenous doses of bambuterol and terbutaline. On a third occasion, they, plus another four subjects, ingested oral bambuterol as a single dose followed by repeated doses once daily for 7 days. Plasma concentrations and urinary excretion of bambuterol and terbutaline were measured. RESULTS After… CONTINUE READING

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