Pharmacokinetics of artesunate following oral and rectal administration in healthy Sudanese volunteers

@article{Awad2004PharmacokineticsOA,
  title={Pharmacokinetics of artesunate following oral and rectal administration in healthy Sudanese volunteers},
  author={Mohamed Ismail Awad and Idris Babiker Eltayeb and Omer Z Baraka and Ron Behrens and A M Y Alkadru},
  journal={Tropical doctor},
  year={2004},
  volume={34 3},
  pages={132-5}
}
The aims of this study were to determine the pharmacokinetic parameters of a single dose of 200 mg oral and rectal artesunate in healthy volunteers, and to suggest a rational dosage regimen for rectal administration. The study design was a randomized open cross-over study of 12 healthy volunteers; the analytical method used was a reversed phase high performance liquid chromatography with post column derivatization and subsequent ultraviolet detection. Pharmacokinetic parameters were derived… CONTINUE READING