Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate.

@article{Cruz2007PharmacokineticsOA,
  title={Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate.},
  author={Adriana Cruz and Petrie M. Rainey and Barbara L. Herwaldt and Grazia Stagni and Ricardo Palacios and Rodolfo A Trujillo and Nancy Gore Saravia},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={195 4},
  pages={602-8}
}
BACKGROUND In some settings, the response to pentavalent antimonial therapy for leishmaniasis may be lower in children than in adults. We hypothesized that there are age-dependent pharmacokinetic differences of potential clinical relevance. METHODS We compared the pharmacokinetics of antimony (Sb) in adults and 2 groups of children 3-6 years old who had cutaneous leishmaniasis treated with intramuscular meglumine antimoniate. Adults (n=9) and the first group of children (n=9) received 20 mg… CONTINUE READING

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