Pharmacokinetics of antimony during treatment of visceral leishmaniasis with sodium stibogluconate or meglumine antimoniate.

@article{Chulay1988PharmacokineticsOA,
  title={Pharmacokinetics of antimony during treatment of visceral leishmaniasis with sodium stibogluconate or meglumine antimoniate.},
  author={JeffreyD. Chulay and Lawrence Fleckenstein and Deborah H. Smith},
  journal={Transactions of the Royal Society of Tropical Medicine and Hygiene},
  year={1988},
  volume={82 1},
  pages={
          69-72
        }
}
5 patients with visceral leishmaniasis were treated with sodium stibogluconate (2 patients) or meglumine antimoniate (3 patients) given intramuscularly at a dose of 10 mg antimony (Sb) per kg body weight daily for 30 d. Blood samples were obtained at intervals during treatment and blood Sb concentrations measured by anodic stripping voltametry. The pharmacokinetics of both drugs were remarkably similar, with peak concentrations of approximately 10 mg/litre occurring 2 h after the initial dose… CONTINUE READING
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