Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients

@inproceedings{Bellmann2017PharmacokineticsOA,
  title={Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients},
  author={Romuald Bellmann and Piotr Smuszkiewicz},
  booktitle={Infection},
  year={2017}
}
Because of the high mortality of invasive fungal infections (IFIs), appropriate exposure to antifungals appears to be crucial for therapeutic efficacy and safety. This review summarises published pharmacokinetic data on systemically administered antifungals focusing on co-morbidities, target-site penetration, and combination antifungal therapy. Amphotericin B is eliminated unchanged via urine and faeces. Flucytosine and fluconazole display low protein binding and are eliminated by the kidney… CONTINUE READING
BETA
50
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS

Clinical Pharmacokinetics of Second-Generation Triazoles for the Treatment of Invasive Aspergillosis and Candidiasis

  • European Journal of Drug Metabolism and Pharmacokinetics
  • 2018
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 440 REFERENCES

Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.

Peter George Pappas, Carol A Kauffman, +9 authors Jack D. Sobel
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2015
VIEW 16 EXCERPTS
HIGHLY INFLUENTIAL

Epidemiology, diagnosis and treatment of fungal respiratory infections in the critically ill patient.

  • Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia
  • 2013
VIEW 18 EXCERPTS
HIGHLY INFLUENTIAL

Voriconazole: a new triazole antifungal agent.

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2003
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…