Pharmacokinetics of antibiotics in neonates

  title={Pharmacokinetics of antibiotics in neonates},
  author={Y. Sato},
  journal={Pediatrics International},
  • Y. Sato
  • Published 1997
  • Medicine
  • Pediatrics International
  • The pharmacodynamics in neonates are different from those in adults and children because the absorption, distribution, metabolism and excretion of drugs in neonates are always changing for the following reasons. In neonates, the proportion of extracellular fluid is large; the amount of plasma protein is small; renal function is immature; and the hepatic enzyme system is immature. In addition, individual birthweights, gestational ages in weeks, cardiopulmonary functions and renal excretory… CONTINUE READING
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