Pharmacokinetics of anti-cancer drugs used in breast cancer chemotherapy.

  title={Pharmacokinetics of anti-cancer drugs used in breast cancer chemotherapy.},
  author={S. Nagar},
  journal={Advances in experimental medicine and biology},
  • S. Nagar
  • Published 2010
  • Medicine
  • Advances in experimental medicine and biology
  • Pharmacokinetics of anticancer drugs used in breast cancer therapy are well established. This chapter reviews preclinical and clinical pharmacokinetics of the following drugs: cyclophosphamide, docetaxel, doxorubicin, 5-fluorouracil, methotrexate and tamoxifen. The absorption, distribution, metabolism and elimination of drugs are discussed in the context of breast cancer. The effect of age and menopause status on drug pharmacokinetics is evaluated. The important role of pharmacokinetic… CONTINUE READING
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