Pharmacokinetics of an oral drug (acetaminophen) administered at various times relative to subcutaneous injection of pramlintide in subjects with type 2 diabetes.

@article{Kellmeyer2007PharmacokineticsOA,
  title={Pharmacokinetics of an oral drug (acetaminophen) administered at various times relative to subcutaneous injection of pramlintide in subjects with type 2 diabetes.},
  author={Terrie A Kellmeyer and Nicole C. Kesty and Yan Wang and Juan P Fr{\'i}as and Mark S Fineman},
  journal={Journal of clinical pharmacology},
  year={2007},
  volume={47 7},
  pages={798-805}
}
Pramlintide, an adjunct treatment to mealtime insulin for patients with type 2 and type 1 diabetes, aids glycemic control by suppressing postprandial glucagon secretion, slowing gastric emptying, and enhancing satiety. Because gastric emptying affects oral medication absorption, this placebo-controlled, single-blind, crossover study examined the absorption of 1000 mg of acetaminophen elixir administered -2, -1, 0, +1, and +2 hours relative to pramlintide (120 microg) or 0 hours relative to… CONTINUE READING