Pharmacokinetics of an elevated dosage of micafungin in premature neonates.

@article{Smith2009PharmacokineticsOA,
  title={Pharmacokinetics of an elevated dosage of micafungin in premature neonates.},
  author={Phillip Brian Smith and Thomas J Walsh and William W Hope and Antonio Arrieta and Akitsugu Takada and Laura L Kovanda and Gregory L. Kearns and David A. S. Kaufman and Taiji Sawamoto and Donald N Buell and Daniel Kelly Benjamin},
  journal={The Pediatric infectious disease journal},
  year={2009},
  volume={28 5},
  pages={412-5}
}
BACKGROUND Determining the safety and pharmacokinetics of antifungal agents in neonates is important. A previous single-dose pharmacokinetic study of micafungin in neonates demonstrated that doses of 0.75 to 3 mg/kg produced lower plasma micafungin concentrations than in older patients because of increased apparent plasma clearance of micafungin in neonates. The primary objective of this study was to assess the safety and pharmacokinetics of an increased (15 mg/kg/d) dose of micafungin… CONTINUE READING