[Pharmacokinetics of afobazole metabolite (M-11) in rats].

Abstract

Pharmacokinetics of compound M-11 (main metabolite of afobazole) after administration via different routes was studied in rats. After oral and intravenous administration, M-11 exhibited weakly pronounced bioconversion with the formation of a few metabolites that could be detected in plasma samples for about 3 hours. The absolute bioavailability of M-11 after oral administration was 68.3%. It was found that M-11 was completely absorbed from gastrointestinal tract of rats and characterized by "the first pass effect", after which approximately 70% of administered dose entered the circulation. The parent substance was determined neither in urine nor in feces.

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@article{Bastrygin2011PharmacokineticsOA, title={[Pharmacokinetics of afobazole metabolite (M-11) in rats].}, author={D. V. Bastrygin and A O Viglinskaia and G. B. Kolyvanov and A. Andrey Litvin and Pavel O Bochkov and T Ia Mozhaeva and Vladimir P. Zherdev}, journal={Eksperimental'naia i klinicheskaia farmakologiia}, year={2011}, volume={74 7}, pages={22-6} }