[Pharmacokinetics of afobazole metabolite (M-11) in rats].


Pharmacokinetics of compound M-11 (main metabolite of afobazole) after administration via different routes was studied in rats. After oral and intravenous administration, M-11 exhibited weakly pronounced bioconversion with the formation of a few metabolites that could be detected in plasma samples for about 3 hours. The absolute bioavailability of M-11 after oral administration was 68.3%. It was found that M-11 was completely absorbed from gastrointestinal tract of rats and characterized by "the first pass effect", after which approximately 70% of administered dose entered the circulation. The parent substance was determined neither in urine nor in feces.


Citations per Year

91 Citations

Semantic Scholar estimates that this publication has 91 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Bastrygin2011PharmacokineticsOA, title={[Pharmacokinetics of afobazole metabolite (M-11) in rats].}, author={D. V. Bastrygin and A O Viglinskaia and G. B. Kolyvanov and A. Andrey Litvin and Pavel O Bochkov and T Ia Mozhaeva and Vladimir P. Zherdev}, journal={Eksperimental'naia i klinicheskaia farmakologiia}, year={2011}, volume={74 7}, pages={22-6} }