Pharmacokinetics of aerosolized tobramycin in adult patients with cystic fibrosis.

@article{Touw1997PharmacokineticsOA,
  title={Pharmacokinetics of aerosolized tobramycin in adult patients with cystic fibrosis.},
  author={D. J. Touw and Fernando Alvarado Jacobs and Roland Brimicombe and Harry G. M. Heijerman and Willem Bakker and D D Briemer},
  journal={Antimicrobial agents and chemotherapy},
  year={1997},
  volume={41 1},
  pages={
          184-7
        }
}
This study was performed to determine the clinical pharmacokinetics of tobramycin in six patients with cystic fibrosis (CF) after inhalation of 600 mg. Tobramycin was administered with an ultrasonic nebulizer (WISTO SENIOR). Blood and urine were sampled until 24 h after inhalation. Maximum tobramycin levels in serum varied from 0.19 to 2.57 mg/liter (mean 1.27 mg/liter; standard deviation, 1.07 mg/liter). Systemic availability (calculated from urinary output) ranged from 6.0 to 27.4% (mean, 17… CONTINUE READING
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