Pharmacokinetics of acetaminophen sulfate after oral administration in rats: analysis of plasma profiles exhibiting a non-linear second peak.

@article{Sawamoto1996PharmacokineticsOA,
  title={Pharmacokinetics of acetaminophen sulfate after oral administration in rats: analysis of plasma profiles exhibiting a non-linear second peak.},
  author={Taiji Sawamoto and Yuji Kurosaki and T. Kimura and Taiji Nakayama},
  journal={Biological \& pharmaceutical bulletin},
  year={1996},
  volume={19 1},
  pages={
          77-82
        }
}
The pharmacokinetics of the two-peak plasma profiles of orally administered acetaminophen sulfate (APAPS), a major conjugated metabolite of acetaminophen (APAP), in rats was examined by a two-compartment model having two delivery routes with individual time lags: a direct delivery route of APAPS absorbed in an unchanged form and an indirect one where APAPS was absorbed as APAP after deconjugation in the lower intestine. Pharmacokinetic parameters were estimated by a non-linear least squares… Expand
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