Pharmacokinetics of acarbose. Part I: Absorption, concentration in plasma, metabolism and excretion after single administration of [14C]acarbose to rats, dogs and man.

@article{Ahr1989PharmacokineticsOA,
  title={Pharmacokinetics of acarbose. Part I: Absorption, concentration in plasma, metabolism and excretion after single administration of [14C]acarbose to rats, dogs and man.},
  author={Hans Juergen Ahr and Michael Boberg and Hans Peter Dr. Krause and William Maul and Fritz Otto M{\"u}ller and H. J. Ploschke and Hannelore Weber and Christian Wuensche},
  journal={Arzneimittel-Forschung},
  year={1989},
  volume={39 10},
  pages={
          1254-60
        }
}
The absorption, disposition, metabolism, and excretion of acarbose (O-4,6-dideoxy-4-[[(1S, 4R, 5S, 6S)-4,5,6-trihydroxy-3- (hydroxymethyl)-2- cyclohexen-1-yl]amino]-a-D-glucopyranosyl- (1----4)-O-a-D-glucopyranosyl- (1----4) -D-glucopyranose, Bay g 5421) have been studied following a single administration of the 14C-labelled compound to rats and dogs via different routes (intravenous, oral, intraduodenal) in the dose range of 2-200 mg.kg-1 as well as to man in a single oral dose of 200 mg… CONTINUE READING

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