Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects

  title={Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects},
  author={Meir Bialer and Abdulla Haj-Yehia and Nicoletta Barzaghi and Francesco Pisani and Emilio Perucca},
  journal={European Journal of Clinical Pharmacology},
The pharmacokinetics of a single 400 mg oral dose of valnoctamide (VCD) has been investigated in seven healthy, adult, male volunteers. VCD was not biotransformed rapidly to its corresponding acid valnoctic acid (VCA), unlike its isomer valpromide (VPD). It had a mean residence time of 13.2 h and a terminal half-life of 9.3 h. Throughout the study, only low plasma levels of VCA could be detected. Thus, unlike VPD, which is a prodrug of the corresponding acid, (valproic acid, VPA). VCD appears… CONTINUE READING


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