Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects

@article{Bialer1990PharmacokineticsOA,
  title={Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects},
  author={Meir Bialer and Abdulla Haj-Yehia and Nicoletta Barzaghi and Francesco Pisani and Emilio Perucca},
  journal={European Journal of Clinical Pharmacology},
  year={1990},
  volume={38},
  pages={289-291}
}
The pharmacokinetics of a single 400 mg oral dose of valnoctamide (VCD) has been investigated in seven healthy, adult, male volunteers. VCD was not biotransformed rapidly to its corresponding acid valnoctic acid (VCA), unlike its isomer valpromide (VPD). It had a mean residence time of 13.2 h and a terminal half-life of 9.3 h. Throughout the study, only low plasma levels of VCA could be detected. Thus, unlike VPD, which is a prodrug of the corresponding acid, (valproic acid, VPA). VCD appears… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 19 references

Anti-Epileptic Agents. II. Diphenylhydantoin, Dipropylacetamide, Valproate and Progabide. In: Johnson FN (ed) Lithium combination treatment

HM Emrich
1987
View 1 Excerpt

Utilization du valpromide en therapeutique psychiatrique

PA Lambert, G Venaud
Enctphale • 1987
View 1 Excerpt

Methods for pharmacokinetic analysis for personal computer

K Yamaoka
2nd edn. Nanko-D Ltd., • 1986
View 1 Excerpt

A comparative pharmacokinetic study of valpromide and valproic acid after intravenous administration in humans

M Bialer, A Rubinstein, J Dubrovsky, I Raz, O Abramsky
Int J Pharm • 1985
View 2 Excerpts

Acute and prophylactic therapies of patients with affective disorders using valpromide (dipropylacetamide). In: Emrich HM, Okama T, Muller A A (eds) Anticonvulsants in Affective Disorders

PA Lambert
Excerpta Medica, • 1984
View 1 Excerpt

Valproate, modern perspectives

RH Levy
Epilepsia 25 [Suppl • 1984
View 1 Excerpt

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