Pharmacokinetics of a prodrug thymoxamine: Dose-dependence of the metabolite ratio in healthy subjects


Thymoxamine, a prodrug, is rapidly deacetylated in the plasma to give two phase I metabolites, DMAT and DAT, which are further sulpho and glucuro-conjugated and then excreted mainly in the urine. In a cross-over study, the dose-dependence of the metabolite ratio was evaluated in nine healthy volunteers after three doses (120, 240, 480 mg) of thymoxarnine… (More)
DOI: 10.1007/BF03189957


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