Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice.

@article{Leroux1995PharmacokineticsOA,
  title={Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice.},
  author={Jean Christophe Leroux and Robert Cozens and Johannes L. Roesel and Bruno Galli and Frank Kubel and Eric Doelker and Robert Gurny},
  journal={Journal of pharmaceutical sciences},
  year={1995},
  volume={84 12},
  pages={1387-91}
}
CGP 57813 is a peptidomimetic inhibitor of human immunodeficiency virus type 1 (HIV-1) protease. This lipophilic compound was successfully entrapped into poly(D,L-lactic acid) (PLA) and pH sensitive methacrylic acid copolymers nanoparticle. The intravenous administration to mice of PLA nanoparticles loaded with CGP 57813 resulted in a 2-fold increase of the area under the plasma concentration-time curve, compared to a control solution. An increase in the elimination half-life (from 13 to 61 min… CONTINUE READING
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