Pharmacokinetics of a loading dose of amikacin in septic patients undergoing continuous renal replacement therapy.

@article{Taccone2011PharmacokineticsOA,
  title={Pharmacokinetics of a loading dose of amikacin in septic patients undergoing continuous renal replacement therapy.},
  author={Fabio Silvio Taccone and Daniel De Backer and P. -F. Laterre and Herbert D M H Spapen and Thierry L Dugernier and Isabelle Karine Delattre and Pierre E Wallemacq and J K Vincent and Fr{\'e}d{\'e}rique Jacobs},
  journal={International journal of antimicrobial agents},
  year={2011},
  volume={37 6},
  pages={531-5}
}
Data on the optimal amikacin regimen during continuous renal replacement therapy (CRRT) are scarce and the proposed loading dose of 10mg/kg may result in inadequate drug levels. The aim of this study was to describe the pharmacokinetics of a 25 mg/kg first dose of amikacin in septic shock patients treated with CRRT. Serum samples were collected before (t=0 h) and at 1 (peak), 1.5, 4.5, 8 and 24 h after a 30-min amikacin infusion in 13 consecutive patients treated with a combination of amikacin… CONTINUE READING

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