Pharmacokinetics of a combination of amikacin sulfate and penicillin G sodium for intravenous regional limb perfusion in adult horses.

@article{Nieto2016PharmacokineticsOA,
  title={Pharmacokinetics of a combination of amikacin sulfate and penicillin G sodium for intravenous regional limb perfusion in adult horses.},
  author={J. C. Estepa Nieto and Jan M Trela and Scott D. Stanley and Sawsan Z Yamout and Jack R. Snyder},
  journal={Canadian journal of veterinary research = Revue canadienne de recherche veterinaire},
  year={2016},
  volume={80 3},
  pages={
          230-5
        }
}
The aim of this study was to determine the pharmacokinetics of amikacin and penicillin G sodium when administered in combination as an intravenous regional limb perfusion (IVRLP) to horses. Seven healthy adult horses underwent an IVRLP in the cephalic vein with 2 g of amikacin sulfate and 10 mill IU of penicillin G sodium diluted to 60 mL in 0.9% saline. A pneumatic tourniquet set at 450 mmHg was left in place for 30 min. Synovial fluid was collected from the metacarpophalangeal joint 35 min… CONTINUE READING