Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application.

@article{Malcolm2014PharmacokineticsOA,
  title={Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application.},
  author={R. Karl Malcolm and Deborah S Lowry and Peter Boyd and Leslie Geer and Ronald S Veazey and Laurie S. Goldman and Per Johan Klasse and Robin J Shattock and John P. Moore},
  journal={The Journal of antimicrobial chemotherapy},
  year={2014},
  volume={69 5},
  pages={1325-9}
}
OBJECTIVES This study measured and compared the pharmacokinetics of CMPD167, a small molecule antiretroviral CCR5 inhibitor with potential as an HIV microbicide, following vaginal, rectal and oral administration in rhesus macaques. METHODS A vaginal hydroxyethylcellulose (HEC) gel, a rectal HEC gel, a silicone elastomer matrix-type vaginal ring and an oral solution, each containing CMPD167, were prepared and administered to rhesus macaques pretreated with Depo-Provera. CMPD167 concentrations… CONTINUE READING
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